|Jung Hie Lee1;Seong Jae Kim2; and Hae Hyuk Jung3;
1;Departments of Psychiatry and
3;Internal Medicine, Kangwon National University College of Medicine, Chuncheon,
2;Department of Neuropsychiatry, Hyosung General Hospital, Cheongju, Korea
Objective : It has been suggested that oxidative stress and inflammation are associated with the pathophysiology of sleep disorders in end-stage renal disease (ESRD) patients. We examined the relationship of the sleep variables reflecting sleep breathing disorder and limb movements during sleep with the clinical variables reflecting the metabolic abnormalities in ESRD patients receiving hemodialysis.
Methods : Nocturnal polysomnography was conducted in 30 ESRD patients (21 men, 9 women), who were receiving hemodialysis. Blood was sampled before hemodialysis for each patient in order to measure uric acid (UA), C-reactive protein (CRP), and interleukin -6 (IL-6).
Results : UA was correlated positively with the total sleep time (TST)(r=0.407) and negatively with the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI)(r=-0.377, -405).
Conclusion : CRP was positively correlated with the limb movement index (LMI)(r=0.401). Our study showed that increased UA was related to decreased respiratory disturbance during sleep in ESRD patients receivings hemodialysis.
End-stage renal disease;Nocturnal sleep;Uric acid;C-reactive protein;Sleep breathing disorder.