Print ISSN 1738-3684
On-line ISSN 1976-3026
 
 
Abstract
Volume 7. Number 1. Pages 49-54 (2010) - Original Article  
   
The Effects of Methylphenidate on Neural Substrates Associated with Interference Suppression in Children with ADHD: A Preliminary Study Using Event Related fMRI
 
Young-Sik Lee1;Doug Hyun Han1;Jang Han Lee2; and Tae Young Choi3;
1;Department of Psychiatry, College of Medicine, Chung Ang University College of Medicine, Seoul,
2;Department of Psychiatry, Chung Ang University, Seoul,
3;Department of Psychiatry, Catholic University of Daegu School of Medicine, Daegu, Korea


Objective : The core deficit of attention deficit hyperactivity disorder (ADHD) is associated with frontal cortex and related circuitry. Children with ADHD and a medication history have shown atypical brain activation in prefrontal and striatal brain regions during cognitive challenge. We investigated two cognitive control operations such as interference suppression (IS) and response inhibition (RI) in children with ADHD. We also assessed the brain functions affected by the methylphenidate (MPH) effect by comparing the blood-oxygen level dependent (BOLD) signals in ADHD children on and off medication. 

Methods : Eight children (9-11 years of age) with combined-type ADHD underwent rapid event-related functional magnetic resonance imaging (fMRI) during performance of a modified flanker task. Two fMRI (3.0 T) scans were conducted with a one week interval-one with MPH treatment and the other without. Functional maps were generated through group averaging and performance-based correlational analyses. 

Results : Performances of the two cognitive control operations did not differ significantly between on-MPH and off-MPH status other than the reaction time to incongruent stimuli in ADHD children. In those affected by MPH treatment, an increased activation in the right prefrontal cortex during incongruent task was observed relative to a neutral trial in children with ADHD.

Conclusion : On the treatment of MPH, the ADHD children exhibited increased activation of the right frontal cortex during interference suppression. This finding suggested that MPH affected the right frontal cortex in ADHD compensating for a reduced level of interference suppression. Future studies will be required to ascertain the MPH effect of cognitive brain regions among large number of children with ADHD.


Key Words
Attention deficit hyperactivity disorder;Methylphenidate;Functional magnetic resonance imaging.
 
   
 


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