Print ISSN 1738-3684
On-line ISSN 1976-3026
 
 
Abstract
Volume 9. Number 2. Pages 166-73 (2012) - Original Article  
   
Adjunctive Memantine Therapy for Cognitive Impairment in Chronic Schizophrenia: A Placebo-Controlled Pilot Study
 
Jung Goo Lee1;Sae Woom Lee2;Bong Ju Lee3;Sung Woo Park4;Gyung Mee Kim3; and Young Hoon Kim5;
1;Department of Psychiatry, Haeundae Paik Hospital, College of Medicine and Paik Institute for Clinical Research, Inje University, Busan,
2;Department of Psychiatry, Jamyung Hospital, Busan,
3;Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Inje University, Busan,
4;Department of Neuroscience Research, Paik Institute for Clinical Research, Inje University, Busan,
5;Department of Psychiatry, Haeundae Paik Hospital, School of Medicine and Paik Institute for Clinical Research, FIRST Research Group, Inje University, Busan, Korea


Objective : To investigate the effects of memantine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on cognitive impairments in patients with chronic schizophrenia.

Methods : A 12-week, placebo-controlled trial was conducted to determine the effectiveness of memantine as an adjunctive treatment with conventional antipsychotic medications in 26 patients with chronic schizophrenia. The subjects were evaluated with the Korean version of the Mini-Mental State Examination (K-MMSE), the Positive and Negative Syndrome Scale (PANSS), the Hamilton Rating Scale for Depression (HAM-D), and a standard neuropsychological screening test.

Results : Memantine treatment was not associated with significantly improved cognitive test scores compared with the placebo control treatment. An improvement in the scores on the PANSS negative subscale was noted with memantine, but it was not significant.

Conclusion : Adjunctive memantine treatment did not improve cognitive functioning or affect psychopathology in patients with chronic schizophrenia in the present study. Memantine, however, was tolerated well and did not exacerbate positive symptoms in patients with chronic schizophrenia.


Key Words
Memantine;Cognition;Antipsychotic drugs;Schizophrenia;Tolerability.
 
   
 


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