|Alessandro Serretti1;Chiara Fabbri1;Silvia Pellegrini2;Stefano Porcelli1;Pierluigi Politi3;Silvio Bellino4;Marco Menchetti1;Veronica Mariotti2;Cristina Demi2;Valentina Martinelli3;Marco Cappucciati3;Paola Bozzatello4;Elena Brignolo4;Paolo Brambilla5;Chi-Un Pae6,7;Matteo Balestrieri5; and Diana De Ronchi1;
1;Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna,
2;Department of Experimental Pathology, Medical Biotechnology, Epidemiology and Infectious Diseases, University of Pisa, Pisa,
3;Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia,
4;Neuroscience Department, Turin University, Turin,
5;Inter-University Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona and DPMSC, Section of Psychiatry, University of Udine, Udine, Italy,
6;Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Republic of Korea,
7;Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated.
Methods : One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417).
Results : IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome.
Conclusion : Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
Antidepressants;Psychotherapy;5-HT;5-HT1A receptor;5-HT2A receptor;Serotonin transporter;COMT;Genes;Polymorphism;Major depression.