|Hyo Shin Kang*1;Woojae Myung*2;Duk L. Na3;Seong Yoon Kim4;Jae-Hong Lee5;Seol-Heui Han6;Seong Hye Choi7;SangYun Kim8;Seonwoo Kim9; and Doh Kwan Kim1,2;
1;Center for Clinical Research, Samsung Biomedical Research Institute, Seoul,
2;Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,
3;Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul,
4;Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul,
5;Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul,
6;Department of Neurology, Konkuk University School of Medicine, Seoul,
7;Department of Neurology, Inha University School of Medicine, Incheon,
8;Department of Neurology, Seoul National University College of Medicine, Seoul,
9;Biostatistics Unit, Samsung Biomedical Research Institute, Seoul, Republic of Korea
Caregivers for patients with Alzheimer's disease (AD) suffer from psychological and financial burdens. However, the results of the relationship between burden and cognitive function, performance of activities of daily living, and depressive symptoms have remained inconsistent. Therefore, the aim of this study was to examine which factors are more significant predictors of heightened burden, cognitive impairment or functional decline, besides neuropsychiatric symptoms.
Methods : A cross-sectional study was conducted in a sample comprised of 1,164 pairs of patients with AD and caregivers from the Clinical Research of Dementia of South Korea study cohorts. The cognitive function of each sub-domain, functional impairments, depressive symptoms, and caregiver burden were assessed using the dementia version of Seoul Neuropsychological Screening Battery (SNSB-D), Barthel Index for Daily Living Activities (ADL), Seoul-Instrumental Activities of Daily Living (S-IADL), the Clinical Dementia Rating Sum of Box (CDR-SB), the Global Deterioration Scale (GDS), the Korean version of the Neuropsychiatric Inventory (K-NPI), and the 15-item Geriatric Depression Scale.
Results : We found that higher severity (higher CDR-SB and GDS scores) and more functional impairment (lower ADL and higher S-IADL scores) were significantly associated with higher caregiver burden. In addition, depressive symptoms of patients (higher Geriatric Depression Scale scores) were associated with higher caregiver burden.
Conclusion : Therefore, interventions to help maintain activities of daily living in patients with AD may alleviate caregiver burden and improve caregiver well-being.
Caregiver;Alzheimer’s disease;Cognition;Activities of daily living.