Print ISSN 1738-3684
On-line ISSN 1976-3026
 
 
Abstract
Volume 11. Number 1. Pages 95-101 (2014) - Case Report  
   
Low-Dose Acetazolamide in the Treatment of Premenstrual Dysphoric Disorder: A Case Series
 
Gabriele Sani1,2;Georgios D. Kotzalidis1;Isabella Panaccione1,3;Alessio Simonetti1,2;Lavinia De Chiara1,2;Antonio Del Casale1;Elisa Ambrosi1;Flavia Napoletano1,2;Delfina Janiri1;Emanuela Danese1;Nicoletta Girardi1;Chiara Rapinesi1;Daniele Serata1;Giovanni Manfredi1,2;Alexia E. Koukopoulos1,2;Gloria Angeletti1,2;Ferdinando Nicoletti3,4; and Paolo Girardi1,2,5;
1;NESMOS Department (Neuroscience, Mental Health, and Sensory Organs), Sapienza University, School of Medicine and Psychology, Sant'Andrea Hospital, Rome,
2;Centro Lucio Bini, Rome,
3;IRCSS NEUROMED, Pozzilli, Isernia,
4;Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University, School of Medicine and Psychology, Rome,
5;Clinica Neuropsichiatrica Villa Rosa, Suore Ospedaliere del Sacro Cuore di Gesù, Viterbo, Italy


The treatment of premenstrual dysphoric disorder (PMDD) is far from satisfactory, as there is a high proportion of patients who do not respond to conventional treatment. The antidiuretic sulfonamide, acetazolamide, inhibits carbonic anhydrase and potentiates GABAergic transmission; the latter is putatively involved in PMDD. We therefore tried acetazolamide in a series of women with intractable PMDD. Here, we describe a series of eight women diagnosed with DSM-IV-TR PMDD, five of whom had comorbidity with a mood disorder and one with an anxiety disorder, who were resistant to treatment and responded with symptom disappearance after being added-on 125 mg/day acetazolamide for 7-10 days prior to menses each month. Patients were free from premenstrual symptoms at the 12-month follow-up. We suggest that acetazolamide may be used to improve symptoms of PMDD in cases not responding to other treatments. GABAergic mechanisms may be involved in counteracting PMDD symptoms.


Key Words
Premenstrual dysphoric disorder;Sulfonamide diuretics;Acetazolamide;GABA transmission.
 
   
 


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