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Psychiatry Investigation 2004;1(1):56-60.
The Gender- and Age-dependency of the Risk for Alzheimer's Disease Conferred by Apolipoprotein E Polymorphism in Koreans
Jin Hyeong Jhoo, MD, PhD1;Ki Woong Kim, MD, PhD2;Young Ju Suh, PhD3;Dong Young Lee, MD, PhD4;Jong Chul Youn, MD5;Jung Hie Lee, MD, PhD6; and Jong Inn Woo, MD, PhD7;
1;Department of Neuropsychiatry, Pundang Jesaeng Hospital, Daejin Medical Center, Seongnam, 2;Department of Psychiatry, Seoul National University College of Medicine, Seoul, 3;BK21 Research Division for Human Life Science, Seoul National University, Seoul
Abstract


Objective
s
The aim of this study is to examine the impact of the apolipoprotein E (APOE) polymorphism on the risk of Alzheimer's disease (AD) in Koreans.

Materials and Methods
We determined the APOE genotype of 303 probable AD patients and 1,052 non-demented normal controls, and compared their genotypic and allelic frequencies. Then, we determined the odds ratios for AD of the APOE polymorphism in the subjects, stratified by age and gender.


Results
The APOE ε4 allele was more prevalent in the AD patients than in the controls (P<0.0001). The APOE ε4 allele increased the risk of AD in a dose-dependent manner; the odds ratios for AD of the APOE ε4-heterozygous and the APOE ε4-homozygous subjects were 3.9 (95%CI=2.8-5.3) and 15.6 (95% CI=6.6-36.7), respectively. The APOE ε4-conferred AD risk was also dependent on the age and gender of the subjects; the odds ratios for AD were highest in the subjects aged 75-79 years and higher in the women than in the men.


Conclusions
The APOE ε4 allele is a significant genetic risk factor for AD and confers the AD risk in a dose-, age-and gender-dependent manner in Koreans.

Key words   Alzheimer's disease (AD);Apolipoprotein E (APOE);Korean;Risk;Age;Gender.
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