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Psychiatry Investigation 2006;3(1):102-6.
Resolution of Amisulpride associated Amenorrhea by Switching to Aripiprazole
Bun-Hee Lee, MD; and Yong-Ku Kim, MD
Department of Psychiatry, Korea University Ansan Hospital, Korea
Abstract


Objective
: TTo report a 4-case series in which amisulpride-induced symptomatic hyperprolactinemia was resolved by switching to aripiprazole.

Case Reports: Four female patients developed symptomatic hyperprolactinemia such as amenorrhea and/or galactorrhea with elevated serum prolactin levels (113.7-230.0 ng/mL) after taking amisulpride (200-800 mg/day). To resolve the problem of symptomatic hyperprolactinemia, reducing the dosage of amisulpride was first tried, however this approach turned out to have no effect. Subsequently, all 4 patients were switched from amisulpride to aripiprazole (10-20 mg/day), upon which their regular menstrual cycles returned and galactorrhea improved, with the normalization of their serum prolactin levels (6.5 15.0 ng/mL) within 4 weeks after switching.


Conclusion
:
Switching to aripiprazole, a partial dopamine agonist, is an effective strategy for the resolution of antipsychotic-induced hyperprolactinemia and associated adverse effects.

Key words   Prolactin;Amisulpride;Amenorrhea;Galactorrhea;Aripiprazole.
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