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Psychiatry Investigation 2007;4(1):38-40.
Increased Low-Density Lipoprotein Cholesterol Levels after 6 Months of Citalopram Treatment in Patients with Panic Disorder
Hyun-Wook Cho, MD; and Bum-Hee Yu, MD, PhD
Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Abstract


Objective
: Panic disorder is associated with an increased cardiovascular risk. Furthermore, several studies reported increased cholesterol levels after treatment with selective serotonin reuptake inhibitors (SSRIs). 


Methods
:
We examined the serum cholesterol levels in 21 panic disorder patients before and after 24 weeks of treatment with citalopram.


Results
:
The levels of serum low-density lipoprotein cholesterol (LDL-C) were significantly increased after the treatment, whereas there were no significant changes in the levels of serum total cholesterol, triglyceride and high-density lipoprotein cholesterol (HDL-C). Significant weight changes were observed as well. 


Conclusions
:
Citalopram should be used with caution when panic patients have high risk of cardiovascular disorders.

Key words   Citalopram;Cholesterol;Panic disorder.


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