The Association between the T102C Polymorphism of Serotonin-2A Receptor Gene and Neurocognitive Function in Obsessive Compulsive Disorder

Brief Report

Psychiatry Investigation 2007;4(1):49-51.

Kyung Jin Lee, MD1;Hye-Ryung Jung, MS2;Joo-Youn Cho, PhD2;Hye Yoon Park, MD3;Do-Hyung Kang, MD1,3;In-Jin Jang, MD, PhD2;Sang-Goo Shin, MD, PhD2; and Jun Soo Kwon, MD, PhD1,3;

¹;Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Seoul, ²;Department of Pharmacology and Clinical Pharmacology Unit, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, ³;Department of Psychi

Abstract

<p class="MsoPlainText" style="word-spacing: 1; line-height: 150%; margin-top: 0; margin-bottom: 0" align="left"><font face="HY중고딕" size="2">Serotonin dysfunction has been implicated in the pathogenesis of obsessive compulsive disorder (OCD). Neurocognitive dysfunction is considered as the core pathology in the OCD. This study aimed to investigate the association of T102C polymorphism of the 5-HT_2A
receptor gene with the neurocognitive function in OCD. Fifty four patients with OCD were participated in this study. Neurocognitive function tests were administered to the patients with OCD. T102C of the 5-HT_2A
gene were analyzed by Polymerase Chain Reaction (PCR) amplification and Restriction Fragment Length Polymorphism (RFLP). The distribution of genotypic patterns of T102C was grouped into T/T genotype (n=16), T/C genotype (n=28) and T/T genotype (n=10). The group of patients with T/T genotype demonstrated significant delayed response time in immediate recall (p=0.036) and delayed recall (p=0.038) of Rey-Osterrieth Complex Figure test which was used to evaluate visuospatial construction ability and visuospatial memory. These results showed that T/T genotype of T102C has higher performance deficit in neurocognitive function tests such as RCFT than the other types. We suggest that T102C genotype may contribute to neurocognitive function and neurocognitive function may serve as a good candidate phenotype for association or linkage studies on OCD.

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Key words Obsessive compulsive disorder;Polymorphism;Genetic;Serotonin 2A receptor;T102C;Neuropsychological tests.