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Psychiatry Investig > Volume 15(2); 2018 > Article
Psychiatry Investigation 2018;15(2):193-199.
DOI: https://doi.org/10.30773/pi.2017.05.14.2    Published online November 7, 2017.
Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling
Yueh-Ming Tai1, Chih-Yuan Ko2,3, Chen-Cheng Lin4, Yu-Yue Wan4, Jing-Yi Chung4, Yia-Ping Liu4,5
1Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
2Respiratory Medicine Center of Fujian Province, Quanzhou, China
3Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
4Laboratory of Cognitive Neuroscience, Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
5Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan
Correspondence  Yia-Ping Liu ,Tel: +886 2 87923100 ext18614, Fax: +886 2 87923153, Email: yiaping@ms75.hinet.net
Received: December 18, 2016   Revised: February 6, 2017   Accepted: May 14, 2017   Published online: November 7, 2017
*Yueh-Ming Tai and Chih-Yuan Ko contributed equally to this study as co-first authors.
Abstract
Objective
Central 5-HT1A receptor is involved in the modulation of sensorimotor gating function. However, its precise role is not clearly defined in developmentally social deprived (isolation rearing, IR) rats featured with impaired sensorimotor gating ability. We therefore aimed to examine the effects of 5HT1A activation on acoustic startle response (ASR) and prepulse inhibition (PPI) in IR rats in a condition of compromised presynaptic 5-HT functions.
Methods
Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletor, 5,7-DHT. Seven days later rats entered a protocol of 8-OH-DPAT, a 5-HT1A agonist, in which locomotor activity, ASR and PPI and their tissue levels of 5-HT were measured.
Results
Our results found that both IR and 5,7-DHT decreased the tissue concentration of 5-HT. IR-induced hyperactivity and gating impairment were unaffected by 5-HT depletion. 8-OH-DPAT strengthened the ASR in IR but not SOC rats and the drug-reduced PPI could be adjusted by 5,7-DHT pretreatment. 8-OH-DPAT at 100 μg/kg enhanced PPI in 5-HT-depleted SOC rats. However for IR rats, 8-OH-DPAT strengthened PPI in sham rats but downgraded it in depletion condition.
Conclusion
The integrity of central 5-HT system is important to 5-HT1A-modulated sensorimotor gating in isolation-reared rats.
Keywords: 5HT1A receptors, Isolation-rearing, Prepulse inhibition, Serotonin
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