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Psychiatry Investig > Volume 15(2); 2018 > Article
Psychiatry Investigation 2018;15(2):141-146.
DOI:    Published online October 30, 2017.
Longitudinal Impact of Depression on Quality of Life in Stroke Patients
Eun-Song Kim1, Ju-Wan Kim1, Hee-Ju Kang1, Kyung-Yeol Bae1, Sung-Wan Kim1, Joon-Tae Kim2, Man-Seok Park2, Ki-Hyun Cho2, Jae-Min Kim1
1Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea
2Department of Neurology, Chonnam National University Medical School, Gwangju, Republic of Korea
Correspondence  Jae-Min Kim ,Tel: +82-62-220-6143, Fax: +82-62-225-2351, Email:
Received: August 31, 2017   Accepted: October 11, 2017   Published online: October 30, 2017
Stroke is associated with significant long-term morbidity and poor quality of life (QOL). Depression is one of the most common complications after stroke and has been associated with QOL cross-sectionally. We investigated the longitudinal impact of depression in the acute phase of stroke on QOL 1 year after stroke.
In total, 423 patients were evaluated 2 weeks after stroke, and 288 (68%) were followed 1 year later. QOL was assessed using the World Health Organization Quality of Life-Abbreviated form (WHOQOL-BREF) at baseline and follow-up. Depression was diagnosed according to Diagnostic and Statistical Manual of Mental Disorders-IV criteria; demographic and clinical characteristics data, including stroke severity, were obtained at baseline. The longitudinal associations of post-stroke depression (PSD) at baseline with QOL across two evaluation points were assessed using a repeated-measures analysis of variance.
The WHOQOL-BREF scores were significantly and persistently lower 1 year after stroke in patients with PSD at baseline compared with those without PSD at baseline independent of demographic and clinical characteristics, including stroke severity.
PSD in the acute phase of stroke is an independent predictor of QOL in both the acute and chronic phases of stroke. Our findings underscore the importance of evaluating depression in the acute phase of stroke.
Keywords: Stroke, Depression, Longitudinal study, Quality of life, Outcome assessment


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