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Psychiatry Investig > Epub ahead of print
[Epub ahead of print]
DOI: https://doi.org/10.30773/pi.2018.08.21.2    Published online October 11, 2018.
Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling
Kuo-Jung Chang1, Yu-Jung Chen1, Jing-Yi Chung2, Chen-Cheng Lin2,3, Yia-Ping Liu2,4,5
1Department of Psychiatry, Hualien Armed Forces General Hospital, Hualien, Taiwan
2Laboratory of Cognitive Neuroscience, Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
3Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
4Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan
5Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan
Correspondence: Yia-Ping Liu ,Tel: +886 2 28264400, Fax: +886 2 28264570, Email: yiaping@ndmctsgh.edu.tw
Received: May 18, 2018   Revised: July 8, 2018   Accepted: August 21, 2018   Published online: October 11, 2018
Abstract

Objective
Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion.
Methods
Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY).
Results
5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors.
Conclusion
The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.
Key words   5-HT1A receptors, Depression, Isolation-rearing, Serotonin


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