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Psychiatry Investig > Epub ahead of print
[Epub ahead of print]
DOI:    Published online January 7, 2019.
Possible Association of the Ubiquitin-Specific Peptidase 46 Gene (USP46) with Affective Temperamental Traits in Healthy Korean Volunteers
Young Jun Boo1,2, Chun Il Park1,2, Hae Won Kim2,3, Se Joo Kim1,2, Jee In Kang1,2
1Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea
2Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
3Department of Medical Education, Yonsei University College of Medicine, Seoul, Republic of Korea
Correspondence: Se Joo Kim ,Tel: +82-2-2228-1620, Fax: +82-2-313-0890, Email:
Correspondence: Jee In Kang ,Tel: +82-2-2228-1620, Fax: +82-2-313-0890, Email:
Received: April 30, 2018   Revised: August 14, 2018   Accepted: October 2, 2018   Published online: January 7, 2019

Ubiquitin-specific peptidase 46 gene (USP46) polymorphisms is part of ubiquitin-proteasome system, which is responsible for dynamic cellular processes such as the regulation of cell cycle. USP46 has been reported to be associated with major depressive disorder. The objective of the present study was to investigate the association of USP46 polymorphisms with affective temperamental traits in healthy subjects.
A total of 557 Korean healthy volunteers were recruited, and 545 subjects (328 male, 217 female) were included in the final analysis. The DNA of the subjects was isolated from saliva samples. Two single-nucleotide polymorphisms (SNPs) rs346005, rs2244291 in USP46 were genotyped. Affective temperaments were assessed using the Korean version of Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire (TEMPS-A).
A significant association was found between rs346005 genotypes and TEMPS-A only in male subjects. In particular, subjects with the CC genotype of rs346005 showed a more depressive temperament than subjects with AA or CA genotypes in males. For rs2244291, there were no associations between the rs2244291 genotypes and TEMPS-A scores.
Some affective temperaments may serve as a genetic predisposing factors for affective disorders, such as depressive disorder, via vulnerability genes related to the ubiquitin-proteasome system.
Key words   Affective temperament, Genetic association study, TEMPS-A, Ubiquitin-proteasome system, USP46
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