Psychiatry Investigation

Original Article

July 16, 2025

Effectiveness of the Maeum Program in a Stabilization-Focused Psychological Intervention for Trauma Survivors

In Mok Oh, Jeongmi Yoon, Euihyun Kwak, Kyungae Kim, Minyoung Sim

Psychiatry Investig. 2025;22(7):741-747.

Objective Although stabilization-centered interventions alleviating posttraumatic symptoms are well known, scant scientific evidence exists examining interventions on individuals who have experienced various traumatic events in South Korea. This study examined...

Original Article

July 10, 2025

Prospective Associations of Serum Tumor Necrosis Factor-Alpha and Employment on Suicidal Behaviors Over 1 Year in Depressive Patients Receiving Psychopharmacotherapy

Ha-Yeon Kim, Ju-Wan Kim, Hee-Ju Kang, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin, Byung Jo Chun, Min-Gon Kim, Jae-Min Kim

Psychiatry Investig. 2025;22(7):748-756.

Objective This study explored both the individual and combined effects of serum tumor necrosis factor-alpha (sTNF-α) levels and employment status on suicidal behavior (SB) in patients with depressive disorders undergoing...

Original Article

June 18, 2025

Combination of Two Primary Screening Instruments (K-SCQ and K-SRS-2) and Setting of New Cutoff Values to Improve Diagnostic Accuracy of Autism Spectrum Disorder in Young Children

Yoojeong Lee, Guiyoung Bong, Da-Yea Song, Heejeong Yoo

Psychiatry Investig. 2025;22(7):757-765.

Objective This study aimed to explore the diagnostic validity of primary screening instruments (Korean version of the Social Communication Questionnaire [K-SCQ] and Korean version of Social Responsiveness Scale second edition...

Original Article

July 10, 2025

Changes in Heart Rate Variability in Adolescent Patients With Tic Disorders: A 1-Year Prospective Study

Hyeju Lee, Nahyung Lee, Yeje Lim, June Christoph Kang, Jeong-An Gim, Moon-Soo Lee

Psychiatry Investig. 2025;22(7):766-774.

Objective This longitudinal study examined the impact of tic disorders on autonomic nervous system function using heart rate variability (HRV) as a biomarker and assessed its association with quality of...

Original Article

July 16, 2025

Investigating the Quality of Family Relationships and Goal Attainment: Analyzing the Mediating Role of Psychological Distress

Arsalan Haider, Kadir Uludag, Huixia Zhou, Li Hong, Zhang Wei

Psychiatry Investig. 2025;22(7):775-785.

Objective Late adolescence and young adulthood are crucial periods when individuals rely on family support to navigate challenges like identity formation and career decisions. Supportive families aid in coping during...

Original Article

July 10, 2025

Increase of α-Synuclein in the Peripheral Blood of Subjects with Methamphetamine Use Disorder

Mi Ran Choi, Younghoon Chon, Joongbum Cho, Changwoo Han, Yeung-Bae Jin, Sang-Rae Lee, Dai-Jin Kim

Psychiatry Investig. 2025;22(7):786-795.

Objective Methamphetamine (MA) use has created significant public health problems worldwide. Its chronic abuse causes neurotoxicity resulting in disruption of neural plasticity and early onset of neurodegenerative diseases. Therefore, there...

Original Article

July 16, 2025

Discriminative Accuracy of Affective Temperaments in Assessing Suicide Risk

Kyeong A Kang, Suyeon Lee, Seong Yoon Kim, C. Hyung Keun Park

Psychiatry Investig. 2025;22(7):796-805.

Objective This study aimed to evaluate whether individual and composite scores of affective temperaments can differentiate high-risk suicide groups among patients with major depressive disorder (MDD) and to compare their...

Original Article

July 10, 2025

Mediating Effect of Psychological Inflexibility, Insomnia, and Resilience on the Association Between Pain and Depression Among Patients With Chronic Pain

Hussein Makhour, Seockhoon Chung

Psychiatry Investig. 2025;22(7):806-812.

Objective Chronic pain, impacting roughly 20% of the population, significantly affects quality of life and productivity. This study explored the mediating effects of psychological inflexibility, insomnia, and resilience on the...

Original Article

July 16, 2025

Problematic Smartphone Use Is Associated With Current and Previous Major Depressive Disorder

Su Jeong Seong, Jin Pyo Hong, Bong-Jin Hahm, Sung Man Chang, Byung-Soo Kim, Dong-Woo Lee, Seong-Jin Cho, Jong-Ik Park, Jee Eun Park, Hong Jin Jeon

Psychiatry Investig. 2025;22(7):813-820.

Objective Although many studies have demonstrated the association between depression and problematic smartphone use (PSU), temporal precedence of this relationship remains controversial. This study aimed to investigate the relationship between...

Original Article

July 16, 2025

Soyasaponin Bb Attenuates Morphine Withdrawal-Induced Anxiety-Like Behaviors in Male Mice by Rescuing GSK-3β/Nrf2 Signaling

Jie Wu, Chenchen Zhu, Yin Shu, Yongli Lu, Lu Liu, Zhigang Xiao, Zicheng Li

Psychiatry Investig. 2025;22(7):821-831.

Objective To examine the effect of Soyasaponin Bb on morphine withdrawal-induced anxiety-like behaviors in male mice and the corresponding mechanism. Methods The chronic intermittent escalating-dose morphine administration paradigm and spontaneous withdrawal...