Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also induce liver injury in cases without those risk factors. We recommend that clinicians should monitor liver function carefully following duloxetine treatment.
Drug-induced liver injury (DILI) is a term that describes abnormalities in liver function tests (LFTs) that are attributable to medication intake.
Eli Lilly and Company informed healthcare professionals that there had been some postmarketing reports of cholestatic jaundice and hepatitis in patients with chronic liver disease or cirrhosis receiving duloxetine in late 2005. In addition, the product labeling was modified by stating that duloxetine should not ordinarily be prescribed to patients with chronic alcohol use or evidence of chronic liver disease.
Duloxetine was approved in Korea for major depressive disorder (MDD), generalized anxiety disorder, and diabetic peripheral neuropathic pain (DPNP) in 2009. It is a balanced and potent serotonin-norepinephrine reuptake inhibitor, and has been prescribed increasingly in Korea. However, data regarding its effects on the liver are not well known in this country. We have previously reported a case of duloxetine-induced liver injury in a patient with MDD.
We have now experienced another three cases involving duloxetine-induced liver injury. Thus, we describe herein a case series of liver injury in patients with MDD. A MEDLINE search revealed no other report related to duloxetine-induced liver injury in Asian patients; this therefore appears to be the first reported case thereof in Asia.
A 22-year-old Korean male visited our clinic due to depression. The patient had no relevant medical history and no history of substance abuse; his laboratory tests were also normal. He was diagnosed with MDD, and initially treated with duloxetine at 30 mg/day. After 3 weeks, the dosage was increased to 60 mg/day. However, the patient had only a partial response and complained of fatigue. Laboratory tests were performed, and his total bilirubin was 1.8 mg/dL and alanine transaminase (ALT) was 60 U/L (See
A 65-year-old Korean female with a 6-month history of MDD was admitted to our hospital. She had attempted suicide by taking 5 mg of clonazepam (ten tablets) before her arrival at the emergency room. Fortunately, the patient's laboratory findings were near normal at that time. The results of LFTs were as follows (See
A 37-year-old Korean male with MDD was admitted to our department in July 2009. This patient had been involved in a traffic accident in December 2008, in which he had suffered an epidural hematoma and facial bone fracture. He submitted to corrective surgery in the Department of Neurosurgery and was medicated with valproate to prevent seizures. In April 2009 he was referred to our department because of depression, at which time venlafaxine and quetiapine were added to the valproate. Thus, between April and July 2009 the patient had been continually medicated with venlafaxine at 75 mg/day, quetiapine at 400 mg/day, and valproate at 1,200 mg/day. After July 2009, venlafaxine was replaced by duloxetine due to the persistence of depression. Laboratory findings including LFTs were normal before duloxetine treatment: total protein, 7.2 g/dL; albumin, 3.9 g/dL; total bilirubin, 0.3 mg/dL; ALT, 22 U/L; and AST, 14 U/L.
After discharge, the patient was maintained on quetiapine (400 mg/day), duloxetine (60 mg/day), and valproate (900 mg/day) combination therapy for 5 months, after which LFTs were repeated. Although he did not complain of any symptoms, the patient's ALT and AST levels had increased to 69 U/L and 42 U/L, respectively, while the other LFT parameters were within normal limits. The patient was observed for a further 3 months without changing medication, and then the LFTs were repeated; ALT and AST levels further aggravated to 197 U/L and 93 U/L, respectively. Duloxetine was therefore discontinued immediately.
Some clinical studies have found a relationship between liver injury and medication with duloxetine. In patients with a normal baseline ALT, both ALT and AST values peaked after 8 weeks of duloxetine medication, and alkaline phosphatase (ALP) steadily increased to a maximum value at 52 weeks.
All of our cases were medicated with duloxetine at a high dosage (60 mg/day). In an analysis that included postapproval trials, the ALT level was higher than three times the upper limit of normal (ULN) in approximately 1% of duloxetine-treated patients; there is evidence that these elevations of ALT and AST are dose dependent.
The US FDA defines DILI as a persistent elevation of at least three times the ULN in ALT levels accompanied by jaundice (total bilirubin greater than or equal to twice the ULN).
Our cases have a temporal relationship between duloxetine treatment and DILI. In case 1 the patient was a young and healthy adult without medical or substance abuse history. Therefore, the cause of DILI could be attributed to duloxetine. In contrast, in case 2 the patient had attempted suicide by taking clonazepam, intoxication with which might be the cause of DILI. However, the LFTs findings after clonazepam overdose were normal and her liver function was aggravated only after duloxetine treatment; discontinuation thereof normalized her liver function. Valproate is also known to cause DILI. However, the liver function of case 3, who was medicated continuously for several months with valproate, venlafaxine, and quetiapine was normal. DILI developed only after venlafaxine was replaced by duloxetine. It is therefore probable that duloxetine alone was responsible for the DILI, or at the very least, a synergic effect of valproate and duloxetine caused his DILI.
Individuals with preexisting chronic liver disease or excessive alcohol consumption are at a greater risk of duloxetine-induced liver injury.
It may be concluded that the administration of duloxetine can induce liver injury in patients with MDD. Although the mechanism underlying the observed liver injury in these cases remains unclear, clinicians should monitor liver function carefully during duloxetine treatment. Further investigations with larger samples are needed.
This study was supported by a grant from National Research Foundation of Korea (NRF) (No. 431-2010-1-E00027).
Normal ranges of LFT parameters in our hospital laboratory
LFT: liver function test, ALT: alanine transaminase, AST: aspartate transaminase