The MAKE Biomarker Discovery for Enhancing anTidepressant Treatment Effect and Response (MAKE BETTER) Study: Design and Methodology

Article information

Psychiatry Investig. 2019;16(10):791-792
Publication date (electronic) : 2019 October 16
doi :
1Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea
2Mental Health Clinic, Chonnam National University Hwasun Hospital, Hwasun, Republic of Korea
3Department of Biomedical Science, Chonnam National University Medical School, and Clinical Trial Center, Chonnam National University Hospital, Gwangju, Republic of Korea
4Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea

Psychiatry Investig 2018;15(5):538-545

In the original publication, the schedule of follow-up assessment was incorrect. The description in the study design and recruitment of the Method section has been changed as follows: Eligible patients with depressive disorders who agreed to participate in the MAKE BETTER study were approached for follow-up assessments at 1, 2, 3, 6 and 9 weeks; 3 months; and every 3 months thereafter up to 2 years to determine the short- and long-term treatment outcomes and clinical course of their depressive disorder. Accordingly, the Table 2 has been changed as follows. The authors sincerely regret these missing errors.

Schedule of assessment for MAKE BETTER study

Article information Continued

Table 2.

Schedule of assessment for MAKE BETTER study

Base-line 1 weeks 2 weeks 3 weeks 6 weeks 9 weeks 3 Month 6 Month 9 Month 12 Month 15 Month 18 Month 21 Month 24 Month
Clinical assessment
Socio-demographic characteristics
Psychological characteristics
Social support
Stress-related status
Outcomes of depression
Depressive symptom
Functional disability
Quality of life
Biological assessment
Blood biomarker
Salivary cortisol (cortisol study only)
Resting BP, body mass index
Treatment related assessment
Antidepressants, dosage, duration
Adverse events

MAKE BETTER: MAKE Biomarker discovery for Enhancing anTidepressants Treatment Effect and Response, BP: blood pressure