| Pre-Treatment Perceived Social Support Is Associated With Chemotherapy-Induced Peripheral Neuropathy in Patients With Breast Cancer: A Longitudinal Study |
Joon Sung Shin1,2 
, Sanghyup Jung2
, Geun Hui Won3
, Sun Hyung Lee1,2
, Jaehyun Kim4
, Saim Jung5
, Chan-Woo Yeom6
, Kwang-Min Lee7
, Kyung-Lak Son8
, Jang-il Kim9
, Sook Young Jeon10
, Han-Byoel Lee9,11,12
, Bong-Jin Hahm1,2,13
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1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea
2Department of Psychiatry and Behavioral Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
3Department of Psychiatry, Chungnam National University Sejong Hospital, Sejong, Republic of Korea
4Department of Medicine, The Central Force for National Defence, Republic of Korea Army Personnel Command, Yongin, Republic of Korea
5Department of Psychiatry, Korea University Ansan Hospital, Ansan, Republic of Korea
6Department of Psychiatry, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Republic of Korea
7Mind Lab the Place Psychiatric Clinic, Seoul, Republic of Korea
8Department of Psychiatry, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
9Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea
10Department of Surgery, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea
11Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
12Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
13Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea |
Correspondence: Bong-Jin Hahm ,Tel: +82-2-2072-2557, Email: hahm@snuh.org
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Received: November 6, 2024 Revised: January 20, 2025 Accepted: February 4, 2025 Published online: April 11, 2025 |
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| Abstract |
Objective
Previous studies have reported an association between cancer-related symptoms and perceived social support (PSS). The objective of this study was to analyze whether Chemotherapy-Induced Peripheral Neuropathy (CIPN), a prevalent side effect of chemotherapy, varies according to PSS level using a validated tool for CIPN at prospective follow-up.
Methods
A total of 39 breast cancer patients were evaluated for PSS using the Multidimensional Scale of Perceived Social Support (MSPSS) prior to chemotherapy and were subsequently grouped into one of two categories for each subscale: low-to-moderate PSS and high PSS. CIPN was prospectively evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy 20 (CIPN20) at five time points. A linear mixed-effects model with square root transformation was employed to investigate whether the CIPN20 scales varied by PSS level and time point.
Results
Statistical analysis of the MSPSS total scale and subscales revealed a significant effect of the friends subscale group and time point on the CIPN20 sensory scale. The sensory scale score of CIPN20 was found to be lower in participants with high PSS from friends in comparison to those with low-to-moderate PSS at 1 month post-chemotherapy (p=0.010).
Conclusion
This is the first study to prospectively follow the long-term effect of pre-treatment PSS from friends on CIPN. Further studies based on larger samples are required to analyze the effects of PSS on the pathophysiology of CIPN. |
| Key words
Perceived social support; Chemotherapy-induced peripheral neuropathy; Adverse effect; Chemotherapy; Breast cancer |
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