Psychiatry Investig Search


Psychiatry Investig > Epub ahead of print
[Epub ahead of print] Published online February 22, 2018.
The Impact of General Medical Conditions in Obsessive-Compulsive Disorder
Andrea Aguglia1, Maria Salvina Signorelli2, Umberto Albert1, Giuseppe Maina1
1“Rita Levi Montalcini” Department of Neuroscience, University of Turin, Psychiatric Unit, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy
2Department of Clinical and Experimental Medicine, AOU Policlinico Hospital, University of Catania, Catania, Italy
Correspondence  Andrea Aguglia ,Tel: +39 011/9026659, Fax: +39 011/9026659, Email:
Received: December 7, 2016   Revised: June 4, 2017   Accepted: June 17, 2017   Published online: February 22, 2018
The co-occurrence of general medical conditions (GMCs) and major psychiatric disorders is well documented. The aim of this study was to assess the prevalence of GMCs in patients with a primary diagnosis of obsessive-compulsive disorder (OCD) and, secondly, to investigate which clinical variables are associated with the presence of a GMC.
Subjects with a primary diagnosis of OCD were included. Socio-demographic and clinical characteristics were collected. GMCs were classified using the ICD-10 and grouped according to the Cumulative Illness Rating Scale (CIRS) in: cardiac, vascular, hematopoietic, respiratory, ear/nose/throat, upper and lower gastrointestinal, hepatic, renal, genitourinary, musculoskeletal, neurologic, endocrine/metabolic. The association between the presence of GMCs and demographic/clinical variables of OCD was investigated.
A total of 162 patients with OCD were included. 78 (48.1%) patients had at least one comorbid GMC. Most frequent GMCs were endocrine/metabolic diseases (25.9%), followed by upper/lower gastrointestinal (20.5%) and cardio-vascular diseases (13.6%). The presence of a GMC was significantly associated with female gender, older age, duration of untreated illness (DUI), and absence of physical activity.
Patients with OCD have high rates of comorbid GMCs. A longer DUI is associated with having at least one GMCs; this might be due to the long-lasting adoption of unhealthy lifestyles, not counterbalanced by appropriate treatment and psychoeducation.
Keywords: Obsessive-compulsive disorder, General medical condition, Cardiovascular disease, Duration of untreated illness, Medical illness


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