1. Ferrari AJ, Baxter AJ, Whiteford HA. A systematic review of the global distribution and availability of prevalence data for bipolar disorder. J Affect Disord 2011;134:1-13. PMID:
21131055.
2. Martinowich K, Schloesser RJ, Manji HK. Bipolar disorder: from genes to behavior pathways. J Clin Invest 2009;119:726-736. PMID:
19339764.
3. Goodwin GM, Anderson I, Arango C, Bowden CL, Henry C, Mitchell PB, et al. ECNP consensus meeting. Bipolar depression. Nice, March 2007. Eur Neuropsychopharmacol 2008;18:535-549. PMID:
18501566.
4. Clements C, Morriss R, Jones S, Peters S, Roberts C, Kapur N. Suicide in bipolar disorder in a national English sample, 1996-2009: frequency, trends and characteristics. Psychol Med 2013;43:2593-2602. PMID:
23510515.
5. Sullivan PF, Daly MJ, O'Donovan M. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 2012;13:537-551. PMID:
22777127.
6. Etain B, Henry C, Bellivier F, Mathieu F, Leboyer M. Beyond genetics: childhood affective trauma in bipolar disorder. Bipolar Disord 2008;10:867-876. PMID:
19594502.
7. Craddock N, Sklar P. Genetics of bipolar disorder. Lancet 2013;381:1654-1662. PMID:
23663951.
8. Cruceanu C, Alda M, Rouleau G, Turecki G. Response to treatment in bipolar disorder. Curr Opin Psychiatry 2011;24:24-28. PMID:
21088584.
9. McCarthy MJ, Leckband SG, Kelsoe JR. Pharmacogenetics of lithium response in bipolar disorder. Pharmacogenomics 2010;11:1439-1465. PMID:
21047205.
10. Smith DJ, Evans R, Craddock N. Predicting response to lithium in bipolar disorder: a critical review of pharmacogenetic studies. J Ment Health 2010;19:142-156. PMID:
20433322.
11. Dallaspezia S, Benedetti F. Melatonin, circadian rhythms, and the clock genes in bipolar disorder. Curr Psychiatry Rep 2009;11:488-493. PMID:
19909672.
12. van der Horst GT, Muijtjens M, Kobayashi K, Takano R, Kanno S, Takao M, et al. Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 1999;398:627-630. PMID:
10217146.
13. Westrich L, Sprouse J. Circadian rhythm dysregulation in bipolar disorder. Curr Opin Investig Drugs 2010;11:779-787.
14. Boland EM, Alloy LB. Sleep disturbance and cognitive deficits in bipolar disorder: toward an integrated examination of disorder maintenance and functional impairment. Clin Psychol Rev 2013;33:33-44. PMID:
23123569.
15. McCarthy MJ, Nievergelt CM, Kelsoe JR, Welsh DK. A survey of genomic studies supports association of circadian clock genes with bipolar disorder spectrum illnesses and lithium response. PLoS One 2012;7:e32091PMID:
22384149.
16. Mendlewicz J. Disruption of the circadian timing systems: molecular mechanisms in mood disorders. CNS Drugs 2009;23(Suppl 2):15-26. PMID:
19708722.
17. Soria V, Martínez-Amorós E, Escaramís G, Valero J, Pérez-Egea R, García C, et al. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology 2010;35:1279-1289. PMID:
20072116.
18. McCarthy MJ, Nievergelt CM, Shekhtman T, Kripke DF, Welsh DK, Kelsoe JR. Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder. Genes Brain Behav 2011;10:852-861. PMID:
21781277.
19. Sachs GS, Thase ME, Otto MW, Bauer M, Miklowitz D, Wisniewski SR, et al. Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 2003;53:1028-1042. PMID:
12788248.
20. A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing R Development Core Team; 2012,Available at:
http://www.R-project.org.
21. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575. PMID:
17701901.
22. Phipson B, Smyth GK. Permutation P-values should never be zero: calculating exact P-values when permutations are randomly drawn. Stat Appl Genet Mol Biol 2010;9:Article39PMID:
21044043.
23. Courtet P, Olié E. Circadian dimension and severity of depression. Eur Neuropsychopharmacol 2012;22(Suppl 3):S476-S481. PMID:
22959112.
24. Coogan AN, Thome J. Chronotherapeutics and psychiatry: setting the clock to relieve the symptoms. World J Biol Psychiatry 2011;12(Suppl 1):40-43. PMID:
21905994.
25. Harvey AG. Sleep and circadian functioning: critical mechanisms in the mood disorders? Annu Rev Clin Psychol 2011;7:297-319. PMID:
21166537.
26. Plante DT, Winkelman JW. Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry 2008;165:830-843. PMID:
18483132.
27. Lee KY, Song JY, Kim SH, Kim SC, Joo E-J, Ahn YM, et al. Association between CLOCK 3111T/C and preferred circadian phase in Korean patients with bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:1196-1201. PMID:
20600471.
28. Partonen T, Treutlein J, Alpman A, Frank J, Johansson C, Depner M, et al. Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med 2007;39:229-238. PMID:
17457720.
29. Johansson C, Willeit M, Smedh C, Ekholm J, Paunio T, Kieseppä T, et al. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology 2003;28:734-739. PMID:
12655319.
30. Dallaspezia S, Lorenzi C, Pirovano A, Colombo C, Smeraldi E, Benedetti F. Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder. Eur Psychiatry 2011;26:138-140. PMID:
21316201.
31. Utge SJ, Soronen P, Loukola A, Kronholm E, Ollila HM, Pirkola S, et al. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS One 2010;5:e9259PMID:
20174623.
32. Li JZ, Bunney BG, Meng F, Hagenauer MH, Walsh DM, Vawter MP, et al. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci U S A 2013;110:9950-9955. PMID:
23671070.
33. Etain B, Milhiet V, Bellivier F, Leboyer M. Genetics of circadian rhythms and mood spectrum disorders. Eur Neuropsychopharmacol 2011;21(Suppl 4):S676-S682. PMID:
21835597.
34. Miyamoto Y, Sancar A. Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals. Proc Natl Acad Sci U S A 1998;95:6097-6102. PMID:
9600923.
35. Thresher RJ, Vitaterna MH, Miyamoto Y, Kazantsev A, Hsu DS, Petit C, et al. Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science 1998;282:1490-1494. PMID:
9822380.
36. Dunlap JC. Common threads in eukaryotic circadian systems. Curr Opin Genet Dev 1998;8:400-406. PMID:
9729714.
37. Reppert SM, Weaver DR. Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol 2001;63:647-676. PMID:
11181971.
38. Ruan GX, Gamble KL, Risner ML, Young LA, McMahon DG. Divergent roles of clock genes in retinal and suprachiasmatic nucleus circadian oscillators. PLoS One 2012;7:e38985PMID:
22701739.
39. Stephenson KM, Schroder CM, Bertschy G, Bourgin P. Complex interaction of circadian and non-circadian effects of light on mood: shedding new light on an old story. Sleep Med Rev 2012;16:445-454. PMID:
22244990.
40. Vitaterna MH, Selby CP, Todo T, Niwa H, Thompson C, Fruechte EM, et al. Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A 1999;96:12114-12119. PMID:
10518585.
41. Wisor JP, O'Hara BF, Terao A, Selby CP, Kilduff TS, Sancar A, et al. A role for cryptochromes in sleep regulation. BMC Neurosci 2002;3:20PMID:
12495442.
42. Partonen T. Clock gene variants in mood and anxiety disorders. J Neural Transm 2012;119:1133-1145. PMID:
22538398.
43. Nievergelt CM, Kripke DF, Remick RA, Sadovnick AD, McElroy SL, Keck PE Jr, et al. Examination of the clock gene Cryptochrome 1 in bipolar disorder: mutational analysis and absence of evidence for linkage or association. Psychiatr Genet 2005;15:45-52. PMID:
15722957.
44. Antypa N, Mandelli L, Nearchou FA, Vaiopoulos C, Stefanis CN, Serretti A, et al. The 3111T/C polymorphism interacts with stressful life events to influence patterns of sleep in females. Chronobiol Int 2012;29:891-897. PMID:
22823872.