Psychiatry Investigation

Review Article

April 11, 2025

The Clinical Utility of Biomarkers in Diagnosing Major Depressive Disorder in Adults: A Systematic Review of Literature From 2013 to 2023

Shi-han Ang, Roger C. Ho, Roger S. McIntyre, Zhisong Zhang, Soon-kiat Chang, Kayla M. Teopiz, Cyrus SH Ho

Psychiatry Investig. 2025;22(4):341-356.

Objective The variety and efficacy of biomarkers available that may be used objectively to diagnose major depressive disorder (MDD) in adults are unclear. This systematic review aims to identify and...

Review Article

April 11, 2025

Go and the Brain: Cognitive and Neural Impacts of Training

Ki Woong Kim

Psychiatry Investig. 2025;22(4):357-364.

Objective This review synthesizes evidence on the cognitive and neural impacts of the strategic board game Go, emphasizing its role in enhancing cognitive functions and inducing neuroplastic changes. Methods We analyzed...

Original Article

April 11, 2025

Exploring the Mediation of Stress and Emotional Exhaustion on Academic Ineffectiveness and Cynicism Among University Students

Cristian Ramos-Vera, Miguel Basauri-Delgado, Yaquelin E. Calizaya-Milla, Jacksaint Saintila

Psychiatry Investig. 2025;22(4):365-374.

Objective This study explored the indirect effects of emotional exhaustion and academic ineffectiveness on the relationship between perceived stress and cynicism in university students, also examining the moderating role of...

Original Article

April 11, 2025

Digital Media Usage Trends Among Children Aged 8–11 Years Before and After the COVID-19

Kyungjun Kim, Saebom Jeon, Sangha Lee, Donghee Kim, Yunmi Shin

Psychiatry Investig. 2025;22(4):375-381.

Objective The coronavirus disease-2019 (COVID-19) pandemic has significantly altered daily life, potentially impacting children’s digital media usage. This study investigates changes in smart device usage among children in South Korea,...

Original Article

April 11, 2025

Exploring the Relationship Between Different Pain Patterns and Depressive Symptom Among Older Koreans: Using Latent Growth Model

Kyu-Hyoung Jeong, Hye-Gyeong Son, Sunghee Kim, Ju Hyun Ryu, Seoyoon Lee

Psychiatry Investig. 2025;22(4):382-388.

Objective The purpose of this study is to identify the types of pain changes that affect older Koreans, as well as their effects on depressive symptom. Methods We analyzed the Korean...

Original Article

April 11, 2025

Emotional Abuse and Neglect, Depression: A Moderated Mediation Model of Neuroticism and Psychological Resilience

Yueyang Hu, Junsong Fei, Jingyi Yue, Ren Gao, Qianqian Song, Xixi Zhao, Songli Mei

Psychiatry Investig. 2025;22(4):389-396.

Objective There were associations between emotional abuse and neglect (EAN) and depression, but few studies had tested potential mechanisms underlying these relationships. We aimed to provide insights on how (the...

Original Article

April 11, 2025

Assessment of Serum Melatonin Levels, Sleep Patterns, and Clinical Symptoms in Children With Autism Spectrum Disorder: A Case-Control Study

Çağlar Charles Daniel Jaicks, Perihan Çam Ray, Özlem Görüroğlu Öztürk, Gonca Gül Çelik, Ayşegül Yolga Tahiroğlu, Zeliha Haytoğlu, Yusuf Döğüş

Psychiatry Investig. 2025;22(4):397-404.

Objective This study aimed to investigate the relationship between serum melatonin levels, sleep habits, and clinical features in children with autism spectrum disorder (ASD) compared to healthy controls. Methods A total...

Original Article

April 11, 2025

An Ethnic Minority Perspective: Association Between Negative Life Events and Depressive Symptoms in Yi Adolescents in China

Qingqing Xiao, Xiaozhen Song, Shoukang Zou, Ying Wang, Tuge Waqi, Li Yin

Psychiatry Investig. 2025;22(4):405-411.

Objective This study explored whether anxiety and core self-evaluation mediate the relationship between negative life events and depressive symptoms in adolescents of the Yi ethnic minority in China. Methods In this...

Original Article

April 11, 2025

Machine Learning Prediction of Attachment Type From Bio-Psychological Factors in Patients With Depression

Yoon Jae Cho, Jin Sun Ryu, Jeong-Ho Seok, Eunjoo Kim, Jooyoung Oh, Byung-Hoon Kim

Psychiatry Investig. 2025;22(4):412-423.

Objective Adult attachment style is linked to how an individual responds to threats or stress and is known to be related to the onset of psychiatric symptoms such as depression....

Original Article

April 11, 2025

Pre-Treatment Perceived Social Support Is Associated With Chemotherapy-Induced Peripheral Neuropathy in Patients With Breast Cancer: A Longitudinal Study

Joon Sung Shin, Sanghyup Jung, Geun Hui Won, Sun Hyung Lee, Jaehyun Kim, Saim Jung, Chan-Woo Yeom, Kwang-Min Lee, Kyung-Lak Son, Jang-il Kim, et al.

Psychiatry Investig. 2025;22(4):424-434.

Objective Previous studies have reported an association between cancer-related symptoms and perceived social support (PSS). The objective of this study was to analyze whether Chemotherapy-Induced Peripheral Neuropathy (CIPN), a prevalent...

Original Article

April 11, 2025

Frontal and Parietal Alpha Asymmetry as Biomarkers for Negative Symptoms in Schizophrenia

Yao-Cheng Wu, Chih-Chung Huang, Yi-Guang Wang, Chu-Ya Yang, Wei-Chou Chang, Chuan-Chia Chang, Hsin-An Chang

Psychiatry Investig. 2025;22(4):435-441.

Objective Negative symptoms in schizophrenia indicate a poor prognosis. However, the mechanisms underlying the development of negative symptoms remain unclear. This study investigated the relationship between negative symptoms in schizophrenia...

Original Article

April 11, 2025

Effects of Methylenetetrahydrofolate Reductase Polymorphism on Clinical Features of High-Risk Psychosis Before Schizophrenia

Lin Wan, Xueqing Han

Psychiatry Investig. 2025;22(4):442-450.

Objective High-risk psychosis before schizophrenia includes individuals at clinical high risk (CHR) and genetic high risk (GHR). Methylenetetrahydrofolate Reductase (MTHFR) gene variants have been identified as risk factors for schizophrenia...

Original Article

March 28, 2025

Pilot Trial: Impact of a Virtual Reality Stress Reduction Program on Healthcare and Information Technology Professionals During the COVID-19 Pandemic

Daeho Kwon, Wooyoung Im, Yunsoo Kim, Jaesung Yoo, Huisu Jeon, Heeyong Choi, Hyeyun Kim

Psychiatry Investig. 2025;22(4):451-461.

Objective This study evaluated the effectiveness of a virtual reality (VR) based stress reduction program tailored for healthcare and information technology (IT) professionals during the coronavirus disease-2019 pandemic. Methods The 2-week...

Original Article

April 11, 2025

Mental and Behavioral Disorders, Comorbidity, and Self-Harm: Results From Korea National Hospital Discharge In-Depth Injury Survey

Mi Jung Rho, Young-Joo Won, Hyun-Sook Lim, Yoo-Kyung Boo

Psychiatry Investig. 2025;22(4):462-474.

Objective Suicide is a complex issue influenced by various factors, including mental illness, economic, and cultural elements. Mental and behavioral disorders are significant contributors to suicide risk, and individuals who...

The Clinical Utility of Biomarkers in Diagnosing Major Depressive Disorder in Adults: A Systematic Review of Literature From 2013 to 2023 Shi-han Ang, Roger C. Ho, Roger S. McIntyre, Zhisong Zhang, Soon-kiat Chang, Kayla M. Teopiz, Cyrus SH Ho Psychiatry Investig. 2025;22(4):341-356. Review Article April 11, 2025 PDF	Go and the Brain: Cognitive and Neural Impacts of Training Ki Woong Kim Psychiatry Investig. 2025;22(4):357-364. Review Article April 11, 2025 PDF
Exploring the Mediation of Stress and Emotional Exhaustion on Academic Ineffectiveness and Cynicism Among University Students Cristian Ramos-Vera, Miguel Basauri-Delgado, Yaquelin E. Calizaya-Milla, Jacksaint Saintila Psychiatry Investig. 2025;22(4):365-374. Original Article April 11, 2025 PDF	Digital Media Usage Trends Among Children Aged 8–11 Years Before and After the COVID-19 Kyungjun Kim, Saebom Jeon, Sangha Lee, Donghee Kim, Yunmi Shin Psychiatry Investig. 2025;22(4):375-381. Original Article April 11, 2025 PDF
Exploring the Relationship Between Different Pain Patterns and Depressive Symptom Among Older Koreans: Using Latent Growth Model Kyu-Hyoung Jeong, Hye-Gyeong Son, Sunghee Kim, Ju Hyun Ryu, Seoyoon Lee Psychiatry Investig. 2025;22(4):382-388. Original Article April 11, 2025 PDF	Emotional Abuse and Neglect, Depression: A Moderated Mediation Model of Neuroticism and Psychological Resilience Yueyang Hu, Junsong Fei, Jingyi Yue, Ren Gao, Qianqian Song, Xixi Zhao, Songli Mei Psychiatry Investig. 2025;22(4):389-396. Original Article April 11, 2025 PDF
Assessment of Serum Melatonin Levels, Sleep Patterns, and Clinical Symptoms in Children With Autism Spectrum Disorder: A Case-Control Study Çağlar Charles Daniel Jaicks, Perihan Çam Ray, Özlem Görüroğlu Öztürk, Gonca Gül Çelik, Ayşegül Yolga Tahiroğlu, Zeliha Haytoğlu, Yusuf Döğüş Psychiatry Investig. 2025;22(4):397-404. Original Article April 11, 2025 PDF	An Ethnic Minority Perspective: Association Between Negative Life Events and Depressive Symptoms in Yi Adolescents in China Qingqing Xiao, Xiaozhen Song, Shoukang Zou, Ying Wang, Tuge Waqi, Li Yin Psychiatry Investig. 2025;22(4):405-411. Original Article April 11, 2025 PDF
Machine Learning Prediction of Attachment Type From Bio-Psychological Factors in Patients With Depression Yoon Jae Cho, Jin Sun Ryu, Jeong-Ho Seok, Eunjoo Kim, Jooyoung Oh, Byung-Hoon Kim Psychiatry Investig. 2025;22(4):412-423. Original Article April 11, 2025 PDF	Pre-Treatment Perceived Social Support Is Associated With Chemotherapy-Induced Peripheral Neuropathy in Patients With Breast Cancer: A Longitudinal Study Joon Sung Shin, Sanghyup Jung, Geun Hui Won, Sun Hyung Lee, Jaehyun Kim, Saim Jung, Chan-Woo Yeom, Kwang-Min Lee, Kyung-Lak Son, Jang-il Kim, et al. Psychiatry Investig. 2025;22(4):424-434. Original Article April 11, 2025 PDF
Frontal and Parietal Alpha Asymmetry as Biomarkers for Negative Symptoms in Schizophrenia Yao-Cheng Wu, Chih-Chung Huang, Yi-Guang Wang, Chu-Ya Yang, Wei-Chou Chang, Chuan-Chia Chang, Hsin-An Chang Psychiatry Investig. 2025;22(4):435-441. Original Article April 11, 2025 PDF	Effects of Methylenetetrahydrofolate Reductase Polymorphism on Clinical Features of High-Risk Psychosis Before Schizophrenia Lin Wan, Xueqing Han Psychiatry Investig. 2025;22(4):442-450. Original Article April 11, 2025 PDF
Pilot Trial: Impact of a Virtual Reality Stress Reduction Program on Healthcare and Information Technology Professionals During the COVID-19 Pandemic Daeho Kwon, Wooyoung Im, Yunsoo Kim, Jaesung Yoo, Huisu Jeon, Heeyong Choi, Hyeyun Kim Psychiatry Investig. 2025;22(4):451-461. Original Article March 28, 2025 PDF	Mental and Behavioral Disorders, Comorbidity, and Self-Harm: Results From Korea National Hospital Discharge In-Depth Injury Survey Mi Jung Rho, Young-Joo Won, Hyun-Sook Lim, Yoo-Kyung Boo Psychiatry Investig. 2025;22(4):462-474. Original Article April 11, 2025 PDF