A Preliminary Analysis of a Polymorphism in DTNBP1 for Schizophrenia: No Support for an Association

Original Article

Psychiatry Investigation 2005;2(2):92-7.

Eun-Jeong Joo, MD, PhD1;Kyu-Young Lee, MD2;Seong Hoon Jeong, MD, PhD3;Yong-Min Ahn, MD, PhD4;Young Jin Koo, MD, PhD1; and Yong Sik Kim, MD, PhD4;

¹;Eulji University School of Medicine, Department of Neuropsychiatry, Daegeon, ²;Clinical Research Institute of Seoul National University Hospital, Seoul, ³;Dongguk University College of Medicine, Department of Psychiatry, Gyeongju, ⁴;Seoul National Unive

Abstract

We tried to replicate the previously reported positive association between Dystrobrevin bindang protein 1 gene (
DTNBP1
) and schizophrenia. Our sample included 241 patients with schizophrenia based on DSM-IV and 194 normal controls. The patient and control groups were matched for their gender proportion and all the subjects were ethnically Koreans. We genotyped P1635 A/G polymorphism (rs3213207) of
DTNBP1
. We could not find association with
DTNBP1
and schizophrenia in this Korean sample. Additional analysis for the subgroup of schizophrenia having familial loading of major psychiatric disorders did not show association, either. In summary,
DTNBP1
is less likely to be a major susceptibility gene for schizophrenia in this Korean population. Further studies with more Single nudeotide polymorphisms (SNPs) for the whole gene sequence including the promoters will be necessary to understand the genetic contribution of
DTNBP1
for the development of schizophrenia in Koreans.

Key words Schizophrenia;Dysbindin;DTNBP1;Gene;Polymorphism;Association.